September 5 – Simultaneously with the cut-down to 53, clubs that have players in the categories of Active/Physically Unable to Perform or Active/Non-Football Injury or Illness must select one of the following options: place player on Reserve/Physically Unable to Perform or Reserve/Non- Football Injury or Illness, whichever is applicable; request waivers; terminate contract; trade contract; or continue to count the player on the Active List.
September 6 – Claiming period for players placed on waivers at the final roster reduction will expire at 12:00 noon, New York time.
September 6 – Upon receipt of the Personnel Notice at approximately 1:00 p.m., New York time, clubs may establish a practice squad of 10 players (clubs participating in the International Player Development Program may sign one additional international player to a Practice Player Contract.) No club, including the player’s prior club, will be permitted to sign a player to a practice player contract until all clubs have received simultaneous notification via the above Personnel Notice that such player’s prior NFL player contract has been terminated via the waiver system.
September 10 – At 12:00 a.m., New York time, the Top 51 Rule expires for all NFL clubs.
September 10, 13-14 – Regular Season Week 1.